Resident Evil: The Final Chapter is a 2016 science fiction action horror film written and directed by Paul W. S. Anderson. It is the sequel to Resident Evil: Retribution (2012) and the sixth and final installment in the Resident Evil film series, which is loosely based on the Capcom survival horror video game series Resident Evil. The film stars Milla Jovovich, Ali Larter, Shawn Roberts, Ruby Rose, Eoin Macken, William Levy, and Iain Glen. In the film, Alice and her friends are betrayed by Albert Wesker, who gathers the entire forces of Umbrella into one final strike against the apocalypse survivors.
It was released on December 23, 2016, in Japan and on January 27, 2017, in the United States in 2D, 3D and IMAX 3D. The film received mixed reviews and grossed over $312 million worldwide, becoming the highest-grossing film in the franchise.
Dr. James Marcus, the original founder of the Umbrella Corporation, had a daughter who was dying of premature aging. Desperate to save her, Marcus discovered the T-virus. Unfortunately, the virus had the side effect of sudden and uncontrollable mutation; in Cape Town, South Africa, a boy dies in a cable car ascending to Table Mountain, then suddenly reanimates and kills the other passengers. Marcus tried to have the program shut down, despite protests from his colleague Dr. Alexander Isaacs to continue to use it. When he refused, Isaacs ordered Albert Wesker to kill Marcus.
Some time after the events of the previous film, Alice awakens in the now-ruined White House, after being betrayed once again by Wesker. While she is searching for survivors, the Red Queen appears and tells Alice she must return to the Hive in Raccoon City within 48 hours, where the Umbrella Corporation has developed an airborne antivirus, which will kill every organism infected by the T-virus, before the remainder of humankind is wiped out. When asked why she is betraying her creators, the Red Queen says that she will explain once Alice arrives at The Hive. Alice destroys a giant mutated flying creature to escape Washington, D.C.
On her way to Raccoon City, Alice is captured by Isaacs, whose clone she previously killed, but she escapes his convoy. Alice later arrives in the now-destroyed Raccoon City and is captured by a group of survivors, consisting of Doc, Abigail, Christian, Cobalt, Razor, and Claire Redfield, who is revealed to be alive after the attack on Arcadia. After learning a group of armored vehicles and a horde of zombies is coming their way, the group prepares to make their last stand. They defeat the enemy forces, although Cobalt is killed in the process. The group later realizes that a second horde is coming in their direction.
With no defenses left, Alice and the crew decide to get to the Hive entrance, located at the bottom of the nuclear bomb crater which destroyed the city. However, Wesker, having taken control of the Hive, releases mutated guard dogs, killing Christian and one of the two survivors who joined the group earlier. Upon arriving at the Hive, the Red Queen appears again to Alice and explains the reason of her betrayal. She revealed that a video was uploaded to her program which contained the recording of the Umbrella executives, including Isaacs, having a meeting regarding the world, formulating a plan to release the T-virus on purpose in order to cleanse the world, save the rich and powerful with cryogenic capsules hidden in the Hive, and later rebuild the world in their image. The Red Queen, although programmed to never hurt an Umbrella employee, was also programmed to value human life, which is why she enlists Alice’s help in order to stop Isaacs. The Red Queen also warns Alice that someone in her group is a spy for Umbrella.
Entering the Hive, the group encounter several traps, resulting in the death of Abigail, who is sliced by a turbine, and Razor, who is eaten by a creature called Bloodshot. After planting bombs around the Hive, Alice confronts the real Isaacs, while she and Claire are captured by Wesker and Doc, Umbrella’s spy. A cryogenic capsule opens, revealing Alicia Marcus, Umbrella’s co-leader and Marcus’s daughter; Alice is revealed to be just a clone of Alicia. Isaacs plans to eliminate Alicia and gain full control of Umbrella, but Alicia then terminates Wesker’s employment with Umbrella, which signals the Red Queen to crush his legs with a security door. Doc tries to shoot Alice, but his gun is empty – as Alice had deduced his treachery earlier – and he is shot dead by Claire.
Encouraged by Alicia’s words, Alice and Claire fight Isaacs. Their battle results in Alice being pushed into the Laser Corridor. She dodges the lasers, and survives, then defeating Isaacs, who is eventually killed by his own clone – the one Alice had encountered en route to the city – and Alice releases the antivirus, killing all of the undead around her. The bombs planted within the Hive explode, killing everyone inside, including Alicia, all the frozen Umbrella employees, and Wesker who was holding the dead-man’s switch given to him by Alice and who subsequently died through blood loss.
Claire later wakes Alice, who survived because the antivirus killed only the T-virus within her body, not the healthy cells. The Red Queen gives Alice an upload of all Alicia’s memories of childhood. Alice rides a motorcycle toward Manhattan, telling that the antivirus carried only by the winds will take years to reach all corners of the globe. Until then, Alice says, her mission is not over, while at the same time glancing in a rear view mirror flying creatures screeching toward her. Undaunted, Alice continues riding into Manhattan.